{"id":6785,"date":"2021-01-21T07:10:28","date_gmt":"2021-01-21T12:10:28","guid":{"rendered":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/?p=6785"},"modified":"2021-05-11T10:17:25","modified_gmt":"2021-05-11T14:17:25","slug":"antibodies-for-vaccine-validation","status":"publish","type":"post","link":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/trending-topics\/antibodies-for-vaccine-validation\/","title":{"rendered":"Antibodies for vaccine validation"},"content":{"rendered":"\n\n\n\t<div class=\"dkpdf-button-container\" style=\" text-align:right \">\n\n\t\t<a class=\"dkpdf-button\" href=\"\/secondary-antibody-resource\/wp-json\/wp\/v2\/posts\/6785?pdf=6785\" target=\"_blank\"><span class=\"dkpdf-button-icon\"><i class=\"fa fa-file-pdf-o\"><\/i><\/span> Download PDF<\/a>\n\n\t<\/div>\n\n\n\n\n\n<p><style>.page-content-container h3 {font-size: 17.5px; color: #009fe3}.page-content-container ul{list-style-type:none}.page-content-container li{margin-top:.2rem;line-height:1.25rem;font-size:14px}.page-content-container li::before{font-family:\"Font Awesome 5 Pro\";display:inline-block;content:\"\\f3c5\";-webkit-transform:rotate(-90deg);transform:rotate(-90deg);margin-left:-20px;margin-right:8px;font-size:.95rem;color:#ED7004;font-weight:600}.redesign-btn-container .fad,.redesign-btn-container .fal,.redesign-btn-container .far,.redesign-btn-container .fas{margin-right:10px}.redesign-btn-container{width:100%;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;margin:1.3rem 0}.redesign-btn-container a{text-decoration:none}.redesign-btn-container a:hover{text-decoration:none}.redesign-btn{border:2px solid #ed7004;padding:7px 13px;font-size:.9rem;font-weight:600;background:#ed7004;color:#fff;cursor:pointer;text-align:center;line-height:1.5rem;margin:0 auto}.redesign-btn:hover{background:#fff;color:#ed7004}@media (max-width:768px){.redesign-btn{font-size:1.05rem}}<\/style>\n<\/p>\n<p><script src=\"https:\/\/kit.fontawesome.com\/904923013f.js\" crossorigin=\"anonymous\"><\/script><\/p>\n<div class=\"page-content-container\">\n<h2><span style=\"font-weight: 400;\">As the world prepares for the rollout of mass immunization in 2021, testing and manufacturing ramps up to ensure that vaccines are safe, effective, and available. A critical component of the development process uses serological tests to assess seroconversion and the efficacy of the vaccines being deployed. Antibodies remain the backbone of immunoassays. Here, we discuss the importance of antibodies as vaccines look to change the landscape of the COVID-19 pandemic.&nbsp;<\/span><\/h2>\n<p><\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-large wp-image-6788\" src=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-content\/uploads\/vaccine-validation-with-Abs-1024x679.jpg\" alt=\"\" width=\"1024\" height=\"679\" srcset=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-content\/uploads\/vaccine-validation-with-Abs-1024x679.jpg 1024w, https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-content\/uploads\/vaccine-validation-with-Abs-300x199.jpg 300w, https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-content\/uploads\/vaccine-validation-with-Abs.jpg 1250w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<h3>SARS-CoV-2 Vaccines<\/h3>\n<p><span style=\"font-weight: 400;\">As we move closer to the global deployment of a vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the need for accurate serological testing is at its peak.&nbsp;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vaccines work by instigating an immune response in the inoculated individual to develop neutralizing antibodies, enabling the body to detect and clear the virus before the infection becomes a disease.&nbsp;<\/span><\/p>\n<h3>Vaccine efficacy &#8211; Monitoring seroconversion<\/h3>\n<p><span style=\"font-weight: 400;\">Tests that can quantitatively measure antibodies generated in response to infection or vaccination are critical in monitoring the immune response in vaccine recipients. Highly sensitive serological tests use immunoglobulins (antibodies) to detect antibodies generated by the immune response. Monitoring the immune response to vaccination aids clinicians in assessing the efficacy of the vaccine to generate an immune response and prevent infection. Not only as a step in clinical trials during vaccine development, but also to evaluate real-world response in patients. <\/span><\/p>\n<h3>Novel treatments<\/h3>\n<p><span style=\"font-weight: 400;\">Although Covid-19 may be mild for many, some cases result in severe disease; novel treatments continue to develop in the wait for vaccine deployment. One therapeutic avenue is plasma donation (plasmapheresis). Serology tests allow antibody levels to be determined in patients who have cleared infection &#8211; indicating their suitability as donors. <\/span><\/p>\n<h3>Seroprevalence<\/h3>\n<p><span style=\"font-weight: 400;\">Knowing the exposure levels of the virus in a population allows virus spread and its associated risk to be calculated and managed, for example, government decision making for the implementation and timing of public containment measures. <\/span><\/p>\n<h3>Production &#8211; challenges for validation<\/h3>\n<p><span style=\"font-weight: 400;\">Increasing production to meet the demands of global vaccine deployment compels manufacturers to achieve consistent quality and efficacy across production batches. Robust and sensitive serological tests enable vaccine manufacturers to assess product efficacy between batches to ensure reliability and efficacy. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Learn more about how immunoassays are important in the fight against COVID-19. .&nbsp;<\/span><\/p>\n<div class=\"redesign-btn-container\"><a class=\"redesign-btn\" href=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/immuno-techniques\/serological-testing-for-diagnostics-and-disease-surveillance\/\"><i class=\"fas fa-graduation-cap\"><\/i>Serological testing for diagnostics and disease surveillance<\/a><br><a class=\"redesign-btn\" href=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/immuno-techniques\/lateral-flow-assays-for-diagnostics\/\"><i class=\"fas fa-graduation-cap\"><\/i>Lateral flow<\/a><\/div>\n<h3>References:<\/h3>\n<ul>\n<li><span style=\"font-weight: 400;\">Long, Q., Deng, H., Chen, J., Hu, J., Liu, B., Liao, P., Lin, Y., Yu, L., Mo, Z., Xu, Y., Gong, F., Wu, G., Zhang, X., Chen, Y., Li, Z., Wang, K., Zhang, X., Tian, W., Niu, C., Yang, Q., Xiang, J., Du, H., Liu, H., Lang, C., Luo, X., Wu, S., Cui, X., Zhou, Z., Wang, J., Xue, C., Li, X., Wang, L., Tang, X., Zhang, Y., Qiu, J., Liu, X., Li, J., Zhang, D., Zhang, F., Cai, X., Wang, D., Hu, Y., Ren, J., Tang, N., Liu, P., Li, Q. and Huang, A., 2020. Antibody responses to SARS-CoV-2 in COVID-19 patients: the perspective application of serological tests in clinical practice.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Masters, P., 2006. The Molecular Biology of Coronaviruses. <\/span><i><span style=\"font-weight: 400;\">Advances in Virus Research<\/span><\/i><span style=\"font-weight: 400;\">, pp.193-292.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Roche.com. 2020. [online] Available at: &lt;https:\/\/www.roche.com\/dam\/jcr:825f8b8c-c7f2-4474-9e56-02037c586924\/en\/18092020-mr-elecsys-anti-sars.pdf&gt; [Accessed 11 November 2020].<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Roche.com. 2020. [online] Available at: &lt;https:\/\/www.roche.com\/dam\/jcr:825f8b8c-c7f2-4474-9e56-02037c586924\/en\/18092020-mr-elecsys-anti-sars.pdf&gt; [Accessed 11 November 2020].<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Shih, H., Wu, C., Tu, Y. and Chi, C., 2020. Fighting COVID-19: A quick review of diagnoses, therapies, and vaccines. <\/span><i><span style=\"font-weight: 400;\">Biomedical Journal<\/span><\/i><span style=\"font-weight: 400;\">, 43(4), pp.341-354.<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Stern, P. L. (2020). Key steps in vaccine development. <\/span><i><span style=\"font-weight: 400;\">Annals of Allergy, Asthma &amp; Immunology,<\/span><\/i> <i><span style=\"font-weight: 400;\">125<\/span><\/i><span style=\"font-weight: 400;\">(1), 17-27. doi:10.1016\/j.anai.2020.01.025<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Zhu, F., Guan, X., Li, Y., Huang, J., Jiang, T., Hou, L., Li, J., Yang, B., Wang, L., Wang, W., Wu, S., Wang, Z., Wu, X., Xu, J., Zhang, Z., Jia, S., Wang, B., Hu, Y., Liu, J., Zhang, J., Qian, X., Li, Q., Pan, H., Jiang, H., Deng, P., Gou, J., Wang, X., Wang, X. and Chen, W., 2020. Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial. <\/span><i><span style=\"font-weight: 400;\">The Lancet<\/span><\/i><span style=\"font-weight: 400;\">, 396(10249), pp.479-488.&nbsp;<\/span><\/li>\n<\/ul>\n<\/div>\n<table class=\"table\">\n<thead>\n<tr>\n<th class=\"span6\">Learn more:<\/th>\n<th class=\"span6\">Do more:<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td class=\"span6\"><a href=\"\/technical\/products\/groups\/anti-human-secondary-antibodies\/serology\">The Importance of Anti-Human Secondary Antibodies for Serological Testing<\/a><\/td>\n<td class=\"span6\"><a href=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/technical-tips\/westernblotting-10tips\/\">Western blotting &#8211; 10 tips for better blots<\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"span6\">\n<a href=\"\/technical\/products\/groups\/anti-human-secondary-antibodies\/serology\/selection\">Designing human serological immunoassays: Key considerations for antibody selection<\/a>\n<\/td>\n<td class=\"span6\"><a href=\"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/technical-tips\/species-on-species-experiments-solutions\/\">Species on species labeling<\/a><\/td>\n<\/tr>\n<tr>\n<td class=\"span6\"><a href=\"\/technical\/products\/antibody-selection\">Choosing your Secondary Antibody<\/a><\/td>\n<td class=\"span6\"><a href=\"https:\/\/www.jacksonimmuno.com\/technical\/products\/VHH-Discovery\">Secondary Antibodies for VHH discovery<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left;\"><\/p>\n\n\n<p><\/p>\n<!-- AddThis Advanced Settings generic via filter on the_content --><!-- AddThis Share Buttons generic via filter on the_content --><!-- AddThis Related Posts generic via filter on the_content -->","protected":false},"excerpt":{"rendered":"<p>Download PDF As the world prepares for the rollout of mass immunization in 2021, testing and manufacturing ramps up to ensure that vaccines are safe, effective, and available. A critical component of the development process uses serological tests to assess seroconversion and the efficacy of the vaccines being deployed. Antibodies remain the backbone of immunoassays. [&hellip;]<!-- AddThis Advanced Settings generic via filter on get_the_excerpt --><!-- AddThis Share Buttons generic via filter on get_the_excerpt --><!-- AddThis Related Posts generic via filter on get_the_excerpt --><\/p>\n","protected":false},"author":3,"featured_media":6788,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"content-type":""},"categories":[20],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/posts\/6785"}],"collection":[{"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/comments?post=6785"}],"version-history":[{"count":30,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/posts\/6785\/revisions"}],"predecessor-version":[{"id":8193,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/posts\/6785\/revisions\/8193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/media\/6788"}],"wp:attachment":[{"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/media?parent=6785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/categories?post=6785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jacksonimmuno.com\/secondary-antibody-resource\/wp-json\/wp\/v2\/tags?post=6785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}