Jackson Immuno Research Inc.
specializing in secondary antibodies and conjugates
Mar 7 19

Anti-Alpaca Secondary Antibodies for Nanotechnology – Part 1

M Lewis

JIR Anti-Alpaca IgG Secondary Antibodies for Nanobody generation

Alpaca and Llama heavy chain only antibodies provide a framework for engineering recombinant antibodies. The monomeric variable domain (VHH) of heavy chain only camelid IgG2 and IgG3 provides a 12-15 kDa domain which is easy to clone and produce at high levels in recombinant systems, is stable to heat and pH extremes, and generally, has good solubility. These antibodies commonly called nanobodies can cross the blood-brain barrier and access other remote locations, combined with tight antigen binding facilitated by a long CDR3 loop. The unique benefits of VHH domain antibodies see them used in a variety of applications, as components of diagnostic kits for small molecule detection, as biosensors and in numerous therapeutic applications such as cancer treatment VHH antibodies are powerful tools for research, diagnostics and therapy.

To optimize the production of camelid-derived antibodies, JIR offers both Anti-Alpaca IgG2+3 and Anti-Alpaca IgG (H+L) for their detection and quantification during library generation.

Listen to JIR’s Chief Operations Officer, David Fancy, PhD introduce Anti-Camelid Secondary Antibodies.

Learn more about JIR Anti-Camelid Secondary Antibodies for nanobody development here

Comments are closed.

  • Recent Posts

    • Autofluorescence

      Download PDF Autofluorescence can present challenges for techniques such as immunohistochemistry (IHC), immunocytochemistry (ICC), and flow cytometry, where it may reduce assay sensitivity by increasing background or may even mask …Read More »
    • Meet the team: Marketing

      Download PDF Jackson ImmunoResearch’s marketing team is a global team, with members in the U.S. and the UK. We are the link between the company and the customers. Our diverse …Read More »
    • Tree planting with QA and R&D

      Download PDF Here at Jackson ImmunoResearch, we are committed to sustainable practices. Outside of our green laboratory initiatives, our team’s latest activities include a tree planting day at Peacedale Preserve …Read More »
    • Fluorogenic DNA-PAINT: Modifying DNA-PAINT For Faster Super-Resolution Imaging

      Download PDF DNA-based Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is an increasingly popular super-resolution microscopy (SRM) technique owing to its relative simplicity. However, DNA-PAINT is hampered by slow …Read More »
    • Your trusted partner for consistent and continuous antibody supply

      Download PDF For more than 43 years, Jackson ImmunoResearch has been a trusted partner to both academic researchers and commercial life science organizations. Our high-quality, cost-effective secondary antibodies, manufactured in …Read More »