Confocal image of human skin innervation. A skin biopsy of finger, 100µm section, immunostained for pan-neuronal marker, protein gene product 9.5, localized with Cy3 (red and yellow) and basement membrane marker, type IV collagen, with Cy2 (green). Epidermal nerve fibers arise from the nerve bundles comprising the subepidermal neural plexus. A Meisner's corpuscle (M) is present in the papillary dermis. Basement membrane labeling delineates the boundary between epidermis (E) and dermis (D) as well as capillaries (C) and a sweat gland duct (SD).
Image contributed by Dr. William R. Kennedy, Department of Neurology, University of Minnesota. Submitted by Dr. Gwen Crabb.